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Prof. Dr. Tom Grossmann

Department of Chemistry and Pharmaceutical Sciences

Tom Grossmann is professor of Organic Chemistry and Chemical Biology.

Personal information

Professor of Chemistry
Chair of Biomimetic Chemistry
Vrije Universiteit Amsterdam
The Netherlands

twitter: @TomNGrossmann

Short CV

Since 2016 - Professor, Vrije Universiteit Amsterdam, The Netherlands
2011-2015 - Group leader, Chemical Genomics Centre and Technical University Dortmund, Germany
2008-2011 - Postdoctoral research with Gregory L. Verdine, Harvard University, USA
2004-2008 - PhD research with Oliver Seitz, Humboldt-Universität zu Berlin, Germany
2003-2004 - Diploma research with K. Peter C. Vollhardt, University of California, Berkeley, USA
1999-2003 - Chemistry studies, Humboldt-Universität zu Berlin, Germany 

Additional Information

Since Apr 2022 - Editorial advisory board member of the Journal of Peptide Science
Since Oct 2021 - Editorial advisory board member of ChemBioChem
Since Sep 2008 - Member of Friends and Supporters of the Young Chemists' Forum
Since Oct 1999 - Member of the German Chemical Society (GDCh)


Major Recent Funding Schemes

  • ERC Proof of Concept Grant by the European Research Council
  • ERC Starting Grant by the European Research Council
  • Emmy Noether Programme by the German research foundation

Selected Publications

  • Nucleic Acids Res. 2021, 49, 12622-12633: Contrained peptides mimic a viral suppressor of RNA silencing
  • Nature Chem. 2020, 12, 331-337: Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns (perspective)
  • Angew. Chem. Int. Ed. 2019, 58, 17351-17358: Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly
  • Angew. Chem. Int. Ed. 201857, 17079-17083: Coiled-coil peptide beacon: A tuneable conformational switch for protein detection
  • Angew. Chem. Int. Ed. 201857, 11164-11170: In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme
  • Cell Chem. Biol. 201724, 958-968: Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions
  • Nature Commun. 20167, 11300: Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
  • Angew. Chem. Int. Ed. 201554, 13796-13800: Redox modulation of PTEN phosphatase activity by hydrogen peroxide and bisperoxidovanadium complexes

Prizes and Awards

  • 19 Feb 2016 - Student teaching award by the Chemistry and Chemical Biology Student Council, Technical University Dortmund, Germany
  • 01 Jan 2014 - Thieme Chemistry Journal Award 2014
  • 05 Dec 2013 - Winner of the ideas competition "Arthrose - muss das sein?" by the German Rheumatology Association (with Dr. Jessica Bertrand)
  • 4 Dec 2009 - Schering Ph.D. award 2008, joint award of Berlin's three universities honoring the best Ph.D. thesis in chemistry
  • 10 Dec 2008 - Fischer-Nernst Ph.D. award 2008 from the Department of Chemistry at the Humboldt-Universität zu Berlin honoring the best Ph.D. thesis
  • 19 Oct 2005 - Fischer-Nernst study award 2005 from the Department of Chemistry at the Humboldt-Universität zu Berlin, Germany

Ancillary activities

  • Incircular B.V. | Amsterdam | | 2021-02-10 - present

Ancillary activities are updated daily