The Biomimetic Chemistry research group led by Prof Dr Tom Grossmann focuses on the design of peptide-derived molecules (so-called peptidomimetics) as modulators of therapeutically relevant biological targets. The research focuses on three main areas:
- Stabilisation of secondary and tertiary structures of peptides
- Chemical post-translational modification of native proteins
- Structural Chemical Biology
The group has expertise in the synthesis of non-natural amino acids, solid-phase synthesis of modified peptides and heterologous protein expression. In addition, biophysical characterisation of ligands with proteins and oligonucleotides is performed using X-ray diffraction, isothermal titration calorimetry and fluorescence polarisation assays (among others).
Group website: www.grossmannlab.com
The following subgroups are associated with this chair:
Dr Sven Hennig: Structural Chemical Biology
Group website: www.svenslab.com
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