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RESPOND Project: Preparedness of Health Systems to Reduce Mental Health and Psychosocial Concerns Resulting from the COVID-19 Pandemic

RESPOND is an EU-funded research project, which ran from 2020 to 2024. The aim of the project was to identify vulnerable groups at risk for mental health problems due to COVID-19 and to understand risk and resilience factors. The project also developed and tested scalable psychological interventions to support those in need and to improve health system preparedness for future pandemics.

A major concern was how health systems, already overwhelmed by the pandemic, could provide mental health care that could be delivered remotely. RESPOND used two WHO psychological interventions to address COVID-19-related distress: Doing What Matters in Times of Stress (DWM) and Problem Management Plus (PM+). These interventions follow a "stepped care" model, beginning with low-intensity support and progressing to more intensive care if necessary.

DWM, a self-help guide based on Acceptance and Commitment Therapy (ACT), helps individuals manage stress, build resilience, and improve coping strategies. PM+ is a five-session intervention targeting depression, anxiety, and PTSD, delivered by non-specialist workers, focusing on problem-solving, stress management, and social support. These interventions have shown to be effective and can be implemented both quickly and at a low cost.

In RESPOND, they were tailored to the context of the pandemic, and delivered to vulnerable groups, such as healthcare workers, migrants, asylum seekers, and refugees. The countries targeted in the project were the Netherlands, Spain, Italy, Belgium, and France. Data from the populations of Sweden, Italy, and Spain were also analysed and compared.

WHO’s scalable interventions were designed to be delivered by trained non-professional helpers, making them cost-effective and adaptable to various populations and contexts. This scalability helps address the global mental health treatment gap, as many individuals with mental health issues lack access to evidence-based care.

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KNOP Department

Clinical, Neuro- & Developmental Psychology

Clinical Psychology Section

RESPOND study on sickness absence published

RESPOND study on sickness absence published

A RESPOND study was published comparing long-term sickness absence among people with common mental disorders before and during the COVID-19 pandemic in Sweden. The pandemic does not appear to have had an impact on long-term sickness absence though some employment branches (trade, transportation, culture, manufacturing, and service sectors) and older people were negatively affected.

Click here to read the full article
Front page of article on sickness absence and the pandemic in Sweden

List of publications

2025

  • Atarodi, V., Mittendorfer-Rutz, E., Morillo-Cuadrado, D., Mediavilla, R., Felez-Nobrega, M., Monistrol-Mula, A., … & Gémes, K. (2025). Specialized mental healthcare use for common mental disorders and prescription of antidepressants before and during the COVID-19 pandemic among working-age refugees and Swedish-born individuals–a nationwide register-based study. BMC Public Health, 25(1), 840. https://doi.org/10.1186/s12889-025-22028-4
  • Compri, B., Turrini, G., Purgato, M., Bryant, R., Cristobal, P., Haro, J. M., ... & Barbui, C. (2025). Context, implementation and mechanisms of impact of a stepped-care WHO psychological intervention for migrants with psychological distress. Cambridge Prisms: Global Mental Health, 12, e62. https://doi.org/10.1017/gmh.2025.10024
  • Felez-Nobrega, M., Giné-Vázquez, I., Monistrol-Mula, A., Melchior, M., Hecker, I., Mittendorfer-Rutz, E., ... & Haro, J. M. (2025). Identifying psychiatric morbidity and co-morbidity patterns associated with COVID-19 mortality. A register-based cohort study from Catalonia. European Psychiatry, 1-33. https://doi.org/10.1192/j.eurpsy.2025.10121
  • Garcia-Vazquez, B., Muñoz-Sanjosé, A., Fernández-López, A., Pérez-de-Ciriza, I., Nocete-Navarro, L., Almaraz-Garzón, E., Martín-Palacios, M. T., Novella, B., Bravo-Ortiz, M. F., Ayuso-Mateos, J. L., Bayón, C., & Mediavilla, R. (2025). A stress-reduction eHealth intervention for healthcare workers in primary care settings: An implementation study. Frontiers in Public Health, 13. https://doi.org/10.3389/fpubh.2025.1600059
  • Hecker, I., Wallez, S., Scarlett, H., Ayuso-Mateos, J. L., Bryant, R., Caggiu, G., … & Melchior, M. (2025). Psychological distress and compliance with sanitary measures during the Covid-19 pandemic. Plos one, 20(7), e0317272. https://doi.org/10.1371/journal.pone.0317272
  • Kirchner, S., Gémes, K., Josefsson, P., Niederkrotenthaler, T., Melchior, M., Haro, J. M., … & Mittendorfer-Rutz, E. (2025). Sickness absence with common mental disorders and antidepressant prescriptions across different employment branches during as compared to before the Covid-19 pandemic—an observational study covering the Swedish population aged 18–65 years. European Journal of Public Health, ckaf145. https://doi.org/10.1093/eurpub/ckaf145
  • Monistrol-Mula, A., Giné-Vázquez, I., Caggiu, G., Conflitti, C., Gemes, K., Hecker, I., … & Felez-Nobrega, M. (2025). SARS-CoV-2 infection and COVID-19 outcomes across mental disorders and the role of sex: A register-based study from Catalonia. Psychiatry Research, 344, 116325. https://doi.org/10.1016/j.psychres.2024.116325
  • Petri-Romão, P., Stoffers-Winterling, J., Doerschner, C., Jurgeit, J., Gödde, P., Hecker, I., Melchior, M., Czepiel, D., Witteveen, A., van der Ven, E., Sijbrandij, M., Mediavilla, R., Ayuso-Mateos, J. L., Smith, P., Lorant, V., Monistrol Mula, A., Haro Abad, J. M., Gémes, K., Mittendorder-Rutz, E., … Lieb, K. (2025). Co-RESPOND: A federated network of cohorts on mental health and adversity during the COVID-19 pandemic. Challenges, solutions and recommendations for retrospective data harmonization. European Journal of Psychotraumatology, 16(1), 2517920. https://doi.org/10.1080/20008066.2025.2517920
  • Petri-Romão, P., Mediavilla, R., Restrepo-Henao, A., Puhlmann, L. M., Zerban, M., Ahrens, K. F., Barbui, C., Basten, U., Bayón, C., Chmitorz, A., Felez-Nobrega, M., Kollmann, B., Lieb, K., McDaid, D., McGreevy, K. R., Melchior, M., Muñoz-Sanjosé, A., Neumann, R. J., Park, A.-L., … Kalisch, R. (2025). Positive appraisal style predicts long-term stress resilience and mediates the effect of a pro-resilience intervention. Nature Communications, 16(1), 10269. https://doi.org/10.1038/s41467-025-65147-7
  • Petri-Romão, P., Martínez-Alés, G., Martinez-Morata, I., Moreno-Küstner, B., Fernández-Jiménez, E., Hecker, I., Melchior, M., Mittendorfer-Rutz, E., Sijbrandij, M., Walter, H., Witteveen, A. B., Ayuso-Mateos, J. L., Bravo-Ortiz, M.-F., Kalisch, R., Puhlmann, L. M. C., & Mediavilla, R. (2025). Resilience changes and occupational resilience factors among healthcare workers during and after the COVID-19 pandemic: A 2-year prospective cohort study. Scientific Reports, 15(1), 29263. https://doi.org/10.1038/s41598-025-09829-8
  • Pinucci, I., Tedeschi, F., Serra, R., Patanè, M., Acartürk, C., Andriani, D., … & Tarsitani, L. (2025). Resilient outcomes in people with a history of mental disorder during the COVID-19 pandemic: an international 2-years longitudinal prospective study. Social Psychiatry and Psychiatric Epidemiology, 1-14. https://doi.org/10.1007/s00127-025-02944-x
  • Purgato, M., Tedeschi, F., Turrini, G., Cadorin, C., Compri, B., Muriago, G., … & Barbui, C. (2025). Effectiveness of a stepped‐care programme of WHO psychological interventions in a population of migrants: results from the RESPOND randomized controlled trial. World Psychiatry, 24(1), 120-130. https://doi.org/10.1002/wps.21281
  • Roos, R., Witteveen, A. B., Barbui, C., Bryant, R., Dontsova, Z., McDaid, D., ... & Sijbrandij, M. (2025). Psychosocial Problems, Daily Functioning, and Help-seeking Behaviour of International Migrant Workers in the Netherlands: A Qualitative Study to Inform the Adaptation of a Scalable Stepped-Care Intervention. Cambridge Prisms: Global Mental Health, 1-47. https://doi.org/10.1017/gmh.2025.10110

2024

  • Czepiel, D., McCormack, C., Da Silva, A. T., Seblova, D., Moro, M. F., Restrepo-Henao, A., … & van der Ven, E. (2024). Inequality on the frontline: A multi-country study on gender differences in mental health among healthcare workers during the COVID-19 pandemic. Cambridge Prisms: Global Mental Health, 11, e34. https://doi.org/10.1017/gmh.2024.18
  • Erdekian, A., Glock, M., Huetter, S., Rueb, M., Riedinger, D., Stoffers-Winterling, J., … & Wiegand, H. F. (2025). Inanspruchnahme psychiatrisch-psychotherapeutischer Versorgung in Deutschland während des ersten Jahres der COVID-19-Pandemie–Systematischer Review und Metaanalyse. Der Nervenarzt, 1-8. https://doi.org/10.1007/s00115-025-01812-y
  • Francia, L., De Giorgi, R., Lara, E., Del Castellar, B. D., Castelletti, C., Rodríguez-Prada, C., … & Mateos, J. L. A. (2024). Treatment coverage for depression in the general Spanish population and the impact of the Covid-19 pandemic. Heliyon. https://doi.org/10.1016/j.heliyon.2024.e32594
  • Klokgieters, S. S., Ungar, M., Penninx, B. W., Glas, L., Rhebergen, D., & Kok, A. A. (2024). How sustainable is resilience? A mixed-methods study on the COVID-19-pandemic as a challenge to resilience resources of older adults who previously recovered from depression. Aging & Mental Health, 1-10. https://doi.org/10.1080/13607863.2024.2326890
  • Lorant, V., Smith, P., Duveau, C., Seeber, K., Bryant, R. A., Mittendorfer-Rutz, E., … & Nicaise, P. (2024). Psychological distress and online advice-seeking in times of COVID-19: vertical and horizontal equity of an e-mental health strategy. Current Psychology, 43(20), 18736-18747. https://doi.org/10.1007/s12144-023-04907-4
  • Mediavilla, R., García-Vázquez, B., McGreevy, K. R., Underhill, J., Bayón, C., Bravo-Ortiz, M. F., … & Ayuso-Mateos, J. L. (2024). Beyond effectiveness in eHealth trials: Process evaluation of a stepped-care programme to support healthcare workers with psychological distress (RESPOND-HCWs). Digital Health, 10, 20552076241287678. https://doi.org/10.1177/20552076241287678
  • Mittendorfer-Rutz, E., Bergström, J., Josefsson, P., Taipale, H., Sijbrandij, M., Witteveen, A., … & Amin, R. (2024). Suicidal behavior in patients with severe mental disorders prior to and during the COVID-19 pandemic. Psychological Medicine, 1-9. https://doi.org/10.1017/S003329172400299X
  • Monistrol-Mula, A., Diaz-Torres, S., Felez-Nobrega, M., Haro, J. M., Medland, S. E., & Mitchell, B. L. (2024). Genetic analyses point to alterations in immune-related pathways underpinning the association between psychiatric disorders and COVID-19. Molecular Psychiatry, 1-8. https://doi.org/10.1038/s41380-024-02643-0
  • du Mortier, J. A., Giltay, E. J., Kok, A. A., van Oppen, P., Eikelenboom, M., Rhebergen, D., … & Visser, H. A. (2024). Contamination fear during the COVID-19 pandemic in patients with lifetime obsessive compulsive disorder and healthy controls: a longitudinal cohort study. Journal of Obsessive-Compulsive and Related Disorders, 100889. https://doi.org/10.1016/j.jocrd.2024.100889
  • Petri-Romão, P., Engen, H., Rupanova, A., Puhlmann, L., Zerban, M., Neumann, R. J., … & Kalisch, R. (2024). Self-report assessment of Positive Appraisal Style (PAS): development of a process-focused and a content-focused questionnaire for use in mental health and resilience research. Plos one, 19(2), e0295562. https://doi.org/10.1371/journal.pone.0295562
  • Stoffers-Winterling, J. M., Wiegand, H. F., Broll, J., Schäfer, S. K., Adorjan, K., Tüscher, O., & Lieb, K. (2025). COVID-19-Pandemie und die psychische Gesundheit in Deutschland: Verlauf, resiliente und vulnerable Gruppen. Der Nervenarzt, 1-6. https://doi.org/10.1007/s00115-025-01824-8
  • Tortelli, A., Figueiredo, N., Martinez, J. V., Roversi, A., Bryant, R., McDaid, D., … & Melchior, M. (2024). Acceptability of an e-mental health self-help intervention aiming to improve psychological distress among persons experiencing unstable housing in France. https://doi.org/10.21203/rs.3.rs-4183398/v1
  • Wiegand, H. F., Adorjan, K., Stoffers-Winterling, J., Scheithauer, S., Schmitt, J., Tüscher, O., … & Lieb, K. (2025). Psychische Gesundheit und psychiatrisch-psychotherapeutische Versorgung als Elemente von „pandemic and crisis preparedness“. Der Nervenarzt, 1-6. https://doi.org/10.1007/s00115-025-01822-w

2023

  • Andersen, A. J., Hecker, I., Wallez, S., Witteveen, A., Lora, A., Mittendorfer-Rutz, E., … & Mary-Krause, M. (2023). Are we equally at risk of changing smoking behavior during a public health crisis? Impact of educational level on smoking from the TEMPO cohort. BMC public health, 23(1), 1016. https://doi.org/10.1186/s12889-023-15799-1
  • Bögemann, S. A., Puhlmann, L. M., Wackerhagen, C., Zerban, M., Riepenhausen, A., Köber, G., … & Kalisch, R. (2023). Psychological Resilience Factors and Their Association With Weekly Stressor Reactivity During the COVID-19 Outbreak in Europe: Prospective Longitudinal Study. JMIR Mental Health, 10(1), e46518. https://doi.org/10.2196/46518
  • García-Vázquez, B., Martínez-Alés, G., Fernández-Jiménez, E., Andreo-Jover, J., Moreno-Küstner, B., Minué, S., … & Mediavilla, R. (2023). Use of psychological interventions among healthcare workers over the 2-year period following the COVID-19 pandemic: A longitudinal study. PLOS ONE, 18(10), e0292932. https://doi.org/10.1371/journal.pone.0292932
  • Lotito, C., Turrini, G., Purgato, M., Bryant, R. A., Felez-Nobrega, M., Haro, J. M., … & Barbui, C. (2023). Views and experiences of migrants and stakeholders involved in social and health care for migrants in Italy during the COVID-19 pandemic: a qualitative study. BMC psychology, 11(1), 164. https://doi.org/10.1186/s40359-023-01208-0
  • Mediavilla, R., Felez-Nobrega, M., McGreevy, K.R., Monistrol-Mula, A., Bravo-Ortiz, M., Bayón, C., … & Ayuso-Mateos, J.L. on behalf of the RESPOND Consortium. (2023). Effectiveness of a mental health stepped-care programme for healthcare workers with psychological distress in crisis settings: a multicentre randomised controlled trial. BMJ Ment Health, 26. http://dx.doi.org/10.1136/bmjment-2023-300697
  • Melchior, M., Figueiredo, N., Roversi, A., Dubanchet, A., Bui, E., Vadell-Martínez, J., … & Tortelli, A. (2023). Addressing mental health problems among persons without stable housing in the context of the COVID-19 pandemic: study protocol for a randomised trial. RESPOND–France. BMC Public Health, 23(1), 1-10. https://doi.org/10.1186/s12889-023-17238-7
  • Moulin, F., Jean, F., Melchior, M., Patane, M., Pinucci, I., Sijbrandij, M., van der Waerden, J., & Galera, C. (2023). Longitudinal impact of the COVID19 pandemic on mental health in a general population sample in France: Evidence from the COMET Study. J Affect Disord, 320, 275-283. https://doi.org/10.1016/j.jad.2022.09.142
  • Purgato, M., Turrini, G., Tedeschi, F., Serra, R., Tarsitani, L., Compri, B., … & Barbui, C. Effectiveness of a stepped-care programme of WHO psychological interventions in migrant populations resettled in Italy: study protocol for the RESPOND randomised controlled trial. Frontiers in Public Health11, 74. https://doi.org/10.3389/fpubh.2023.1100546
  • Roos, R., Witteveen, A. B., Ayuso-Mateos, J. L., Barbui, C., Bryant, R. A., Felez-Nobrega, M., … & Sijbrandij, M. on behalf of the RESPOND Consortium. (2023). Effectiveness of a scalable, remotely delivered stepped-care intervention to reduce symptoms of psychological distress among Polish migrant workers in the Netherlands: study protocol for the RESPOND randomised controlled trial. BMC psychiatry, 23(1), 801. https://doi.org/10.1186/s12888-023-05288-5
  • Witteveen, A. B., Young, S. Y., Cuijpers, P., Ayuso-Mateos, J. L., Barbui, C., Bertolini, F., … & Sijbrandij, M. (2023). COVID-19 and common mental health symptoms in the early phase of the pandemic: An umbrella review of the evidence. PLoS Medicine, 20(4), e1004206. https://doi.org/10.1371/journal.pmed.1004206

2022

  • Camara, C., Surkan, P. J., Van Der Waerden, J., Tortelli, A., Downes, N., Vuillermoz, C., & Melchior, M. (2023). COVID-19-related mental health difficulties among marginalised populations: A literature review. Cambridge Prisms: Global Mental Health, 10, e2. https://doi.org/10.1017/gmh.2022.56
  • Hecker, I., El Aarbaoui, T., Wallez, S., Juhl Andersen, A., Ayuso-Mateos, J. L., Bryant, R., Corrao, G., McDaid, D., Mediavilla, R., Mittendorfer-Rutz, E., Monzio Compagnoni, M., Park, A., Riepenhausen, A., Rigotti, T., Seeber, K., Sijbrandij, M., Smith, P., Tüscher, O., Walter, H., Witteveen, A., Mary-Krause, M., & Melchior, M. (2022). Impact of work arrangements during the COVID-19 pandemic on mental health in France. SSM – Population Health. https://doi.org/10.1016/j.ssmph.2022.101285
  • Mediavilla, R., McGreevy, K. R., Felez-Nobrega, M., Monistrol-Mula, A., Bravo-Ortiz, M. F., Bayón, C., … & RESPOND Consortium. (2022). Effectiveness of a stepped-care programme of internet-based psychological interventions for healthcare workers with psychological distress: Study protocol for the RESPOND healthcare workers randomised controlled trial. Digital Health, 8. https://doi.org/10.1177/20552076221129084
  • Mediavilla, R., Monistrol-Mula, A., McGreevy, K. R., Felez-Nobrega, M., Delaire, A., Nicaise, P., Palomo-Conti, S., Bayón, C., Bravo-Ortiz, M.-F., Rodríguez-Vega, B., Witteveen, A., Sijbrandij, M., Turrini, G., Purgato, M., Vuillermoz, C., Melchior, M., Petri-Romão, P., Stoffers-Winterling, J., Bryant, R. A., McDaid, D., Park A.-L., Ayuso-Mateos, J. L. and RESPOND Consortium. (2022). Mental health
    problems and needs of frontline healthcare workers during the COVID-19 pandemic in Spain: A qualitative analysis. Front. Public Health, 10:956403. https://doi.org/10.3389/fpubh.2022.956403
  • Penninx, B. W. J. H., Benros, M. E., Klein, R. S., & Vinkers, C. H. (2022). How COVID-19 shaped mental health: from infection to pandemic effects. Nature medicine28(10), 2027–2037. https://doi.org/10.1038/s41591-022-02028-2
  • Riepenhausen, A., Veer, I. M., Wackerhagen, C., Reppmann, Z. C., Köber, G., Ayuso-Mateos, J. L., … & Walter, H. (2022). Coping with COVID: risk and resilience factors for mental health in a German representative panel study. Psychological medicine, 1-11. https://doi.org/10.1017/S0033291722000563
  • Schäfer, S. K., Kunzler, A. M., Kalisch, R., Tüscher, O., & Lieb, K. (2022). Trajectories of resilience and mental distress to global major disruptions. Trends in Cognitive Sciences. https://doi.org/10.1016/j.tics.2022.09.017
  • Witteveen, A. B., Young, S., Cuijpers, P., Ayuso-Mateos, J. L., Barbui, C., Bertolini, F., Cabello, M., Cadorin, C., Downes, N., Franzoi, D., Gasior, M., John, A., Melchior, M., McDaid, D., Palantza, C., Purgato, M., Van der Waerden, J., Wang, S., & Sijbrandij, M. (2022). Remote mental health care interventions during the COVID-19 pandemic: An umbrella review. Behaviour research and therapy159, 104226. https://doi.org/10.1016/j.brat.2022.104226

2021

  • Ayuso-Mateos, J. L., Morillo, D., Haro, J. M., Olaya, B., Lara, E., & Miret, M. (2021). Changes in depression and suicidal ideation under severe lockdown restrictions during the first wave of the COVID-19 pandemic in Spain: A longitudinal study in the general population. Epidemiology and Psychiatric Sciences, 30. https://doi.org/10.1017/S2045796021000408
  • Kunzler, A. M., Röthke, N., Günthner, L., Stoffers-Winterling, J., Tüscher, O., Coenen, M., Rehfuess, E., Schwarzer, G., Binder, H., Schmucker, C., Meerpohl, J. J., & Lieb, K. (2021). Mental burden and its risk and protective factors during the early phase of the SARS-CoV-2 pandemic: Systematic review and meta-analyses. Globalization and Health, 17(1), 34. https://doi.org/10.1186/s12992-021-00670-y

List of reports and policy briefs

These documents reflect only the authors’ views and the European Commission is not responsible for any use of the information they contain.

Funding

Funding

This project received funding from the European Union’s Horizon 2020 research and innovation programme Societal Challenges under Grant Agreement No 101016127.

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Faculty of Behavioural and Human Movement Sciences (FGB)
Department of Clinical, Neuro- & Developmental Psychology
Van der Boechorststraat 7
1081 BT Amsterdam

Contact

  • Marit Sijbrandij, PhD
  • Full Professor, Clinical Psychology
  • Faculty of Behavioural and Movement Sciences
  • e.m.sijbrandij@vu.nl
Marit Sijbrandij, PhD

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