It concerns:
Tell me how it begins, I will tell you how it ends: catching transcription at the start of physicist David Dulin
To function, our cells need proteins, which are made by ribosomes, which are partly constituted of ribosomal RNAs synthesized in our cells by RNA polymerase 1 (Pol I). Pol I activity is essential during cell growth, and central in the development of many cancers. Ribosome assembly is mainly regulated at the start of ribosomal RNA synthesis by Pol I. Here, Dulin will employ cutting edge biophysics techniques to reveal how this process is controlled one Pol I molecule at a time.
Age-Related Skeletal Muscle Decline: Integrative Insights from Physiology to Molecular Regulation of physiologist Richie Goulding
Goulding aims to unravel the mechanisms underlying age-related skeletal muscle dysfunction. Using innovative techniques involving near-infrared spectroscopy (NIRS), as well as advanced microscopy and phosphoproteomics, he will assess mitochondrial function, muscle diffusive capacity, the muscle structures underlying these functions and their molecular regulation in young, middle-aged, and elderly individuals. Additionally, he will investigate the effects of endurance training on mitochondrial function in middle-aged subjects. By understanding how ageing impacts muscle function and exploring exercise interventions, he aims to contribute to both scientific knowledge and potential clinical applications for improving health outcomes in ageing populations.
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Super-speed Optical Coherence Tomography of physicist Dierck Hillmann en Lyuba Amitonova
Optical coherence tomography (OCT) is an imaging technique used primarily in ophthalmology to characterize the morphology and function of retinal tissue in living humans. An important feature of OCT is its acquisition speed –faster acquisition provides clearer images and more information can be extracted from the data. Hillmann and Amitonova will develop a super-speed OCT technique that can increase the speed of the fastest available OCT systems by a factor of 10 or drastically reduce the cost of existing OCT systems. This will pave the way for new applications of OCT in the future.
Read about the other awards on the NWO website