Education Research Current Organisation and Cooperation NL
Login as
Prospective student Student Employee
Bachelor Master VU for Professionals
Exchange programme VU Amsterdam Summer School Honours programme VU-NT2 Semester in Amsterdam
PhD at VU Amsterdam Research highlights Prizes and distinctions
Research institutes Our scientists Research Impact Support Portal Creating impact
News Events calendar Energy in transition
Israël and Palestinian regions Women at the top Culture on campus
Practical matters Mission and core values Entrepreneurship on VU Campus
Organisation Partnerships Alumni University Library Working at VU Amsterdam
Sorry! De informatie die je zoekt, is enkel beschikbaar in het Engels.
This programme is saved in My Study Choice.
Something went wrong with processing the request.
Something went wrong with processing the request.

Physicist Chase Broedersz receives ERC Consolidator Grant

Share
23 November 2023
The European Research Council (ERC) awards Chase Broedersz, associate professor at Vrije Universiteit Amsterdam, a Consolidator Grant for his project “Learn4DChromosome”. Chromosomes contain the genetic information to produce life and wants to understand the physical principles of functional chromosome organisation in bacteria.

4D model
The central goal of Learn4DChromosome is to develop a 4D model for the statistical folding of chromosomes and its implications for function. The development of new experimental Hi-C, chromosome, techniques has recently generated a breakthrough in measuring chromosome structure. Unlike a microscope, however, these experiments don’t yield easily interpretable images, but rather a statistical metric for average pairwise interactions between chromosomal regions. Interpreting Hi-C maps at their full quantitative potential remains a major hurdle to overcome. 

Physics of living systems
Chase Broedersz is theoretical physicist at the VU Amsterdam Department of Physics. His research group studies the Physics of Living Systems, like bacteria. Bacteria play a major role in human health and disease. Bacterial chromosomes not only have to be highly condensed to fit inside the cell, but their organisation must also facilitate vital processes such as gene transcription, DNA replication, and segregation.

“Bacterial chromosomes are not folded in a completely random fashion, like a regular polymer. Nor are they folded in a regular structure, like many proteins. It’s something in between that I term statistical chromosome folding, which is highly controlled by the cell. This statistical folding characterizes the inherently variable and dynamic nature of chromosomes. Understanding the statistical organisation of chromosome organisation in living, growing, and replicating bacteria is a major outstanding challenge’’, says Chase Broedersz.

Ambitious goals
When asked about the most ambitious goals of his project, Broedersz says: “Developing a theoretical ‘lens’ that decodes the information in Hi-C maps, thereby providing not only direct ‘pictures’ but also ‘movies’ for the 4D statistical organisation of bacterial chromosomes.” The key to Broedersz’ data-driven theoretical approach is to combine information and physics-guided learning techniques. Beyond offering new insight into key biological processes like how chromosomes separate before cell division, the results and tools developed in Learn4DChromosome may help unravel how bacterial chromosomes respond to genetic perturbations and drug treatments like anti-biotics.

Quick links

Homepage Culture on campus VU Sports Centre Dashboard

Study

Academic calendar Study guide Timetable Canvas

Featured

VUfonds VU Magazine Ad Valvas

About VU

Contact us Working at VU Amsterdam Faculties Divisions
Privacy Disclaimer Veiligheid Webcolofon Cookies Webarchief

Copyright © 2024 - Vrije Universiteit Amsterdam