Cell models and organisms (e.g. snail, zebrafish) are used to study specific molecular pathways (e.g. neurotoxicity, endocrine disruption), or so called untargeted metabolomics is carried to perform discovery analysis. Hundreds or even thousands of metabolites simultaneously, and the potential to rapidly assess many aspects of an organism’s current energetic, oxidative, endocrine, and reproductive status.
One of the main drives is to anchor the metabolite profiles to organism’s functioning, phenotypical changes, health effects, and chemical exposure. We try to relate chemical exposure to molecular mechanisms and adverse health effects.
DENAMIC: Developmental neurotoxicity of chemical mixtures in children
WhaleHealth: Contaminant levels and effects in killer and humpback whales in Norway