We develop analytical methods to determine nucleoside triphosphate (NTP) and deoxy nucleotides (dNTP) in cells and tissues. Besides these triphosphates the analytical methods also includes the determination of the di- and monophosphate (dexoy)nucleosides which all are part of the purine and pyrimidine pathways. Chemicals can affect the (d)NTP pools and are related to development of cancer and neurodevelopmental disorders.
- Prof.dr. Pim Leonards