Analytical chemist Julien Slagboom developed new methods to analyse snake venom faster and more precisely. This will make it possible to reduce the number of snakebite victims already within a few years.
Snake bites cause more than half a million serious poisonings worldwide every year, especially in places in Southeast Asia, Latin America and Africa where medical care is not easily accessible. The antidotes we use today are often difficult to access, can cause side effects and do not work against bites of all snake species. As a result, people die from snake bites, or become disabled.
Distinguishing different toxins
Snake venom is very complex and consists of dozens to hundreds of different toxins. Slagboom therefore investigated how we can better distinguish these different toxins and link them to their harmful effects.
In the laboratory, Slagboom separated different types of snake venom into smaller parts so that he could see exactly which substances they contain. He then tested these parts with modern measuring equipment that can accurately determine which proteins are present. He also performed bioassays: tests that allow you to see what a venom does, such as make blood clot or paralyse someone.
New analysis methods
Slagboom: "By combining these measurement results and test data, I was able to get a clear picture of which toxins are most dangerous and how they work. I also developed new analysis methods that make this process faster and more efficient."
With the new analytical methods, scientists and pharmacists can develop better, safer and affordable antidotes. For instance, they can test new antibodies that neutralise exactly the right toxins from a snake bite. Within just any number of years, this could contribute to new treatments that save many lives worldwide.
Slagboom will defend his thesis on 31 October. Read the entire thesis via this website.