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Venom to Victory: Harnessing organ-on-a-chip for drug discovery

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11 December 2024
Researchers Jeroen Kool, Matyas Bittenbinder and Julien Slagboom from the department of Chemistry & Pharmaceutical sciences (CPS) at the Vrije Universiteit Amsterdam got their project on finding peptides from snake venoms with anticancer properties granted within TKIchemie, Health-Holland.

Snake venoms contain a rich source of bioactive molecules that exhibit a wide range of pharmacological activities. The potency and selectivity of these compounds offers great for drug discovery, with recent studies suggesting the use of snake venom as a source for novel anticancer therapies. In this proposal, the Vrije Universiteit’s Venom Research Group will collaborate with the organ-on-a-chip company MIMETAS to develop and apply organ-on-a-chip models for profiling snake venom toxins as potential anticancer drug leads.

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