On October 30, chemical biologist Mátyás Bittenbinder received his doctorate at the Vrije Universiteit Amsterdam with research on the pathological effects of snake venom on the human body. The research is conducted within the department of Chemistry and Pharmaceutical Sciences; division of BioAnalytical Chemistry, together with Naturalis Biodiversity Center, involved working with analytical techniques to also identify and characterize”
Each year, more than 100,000 people die from snakebite effects, while over 400,000 others suffer permanent damage, such as blindness and amputations. Bittenbinder's research focused on understanding the biochemical mechanisms behind cell and tissue damage, with the ultimate goal of developing more effective antivenoms and other new snakebite treatments. The research utilized cell cultures and advanced fluorescence microscopes to study the effects of venom on living cells in real-time. Additionally, 3D models of blood vessels were used to demonstrate how snake venom damages blood vessels and can cause bleeding.
A key part in his research, conducted within the department of Chemistry and Pharmaceutical Sciences, involved working with analytical techniques to also identify and characterize the pathological toxins in venoms chemically. Bittenbinder hopes that his findings will contribute to the development of new snakebite treatment drugs focused on tissue repair, which could lead to a better survival rate and higher quality of life for snakebite victims. The doctoral ceremony was introduced by an inspiring mini symposium, where the opponents shared their own research with the audience.
Promotor Prof. Dr. Freek Vonk, known for his expertise in reptiles and snake venom, handed over the diploma after the defense, and promotor Dr. Jeroen Kool concluded the PhD ceremony with personal and grateful words.
Watch a short video about Mátyás Bittenbinder here.