|The diaphragm, the main respiratory muscle, is composed of an intricate clockwork of numerous proteins. Inherited defects in these proteins make the clockwork lock, with life-threatening diseases as a result. Physiologist Coen Ottenheijm (Amsterdam UMC, VUmc) will study how the clockwork locks and which keys there are to unlock.
|Jolanda van der Velden receives the Vici grant for her research "The fight against toxic protein in hereditary heart diseases". A large number of people are carriers of a genetic defect in DNA that causes them to develop heart disease at a young age. Those people then get a very large heart, hypertrophic cardiomyopathy, that can not relax properly. In this study, we will be testing a number of medicines that may possibly prevent or inhibit this heart disease.
|Albert Menkveld, receives the Vici grant for his research project 'Financial Techology (FinTechs) Disruptive Impact on Financial Markets: social costs and benefits of an emerging new architecture'. FinTech is rapidly changing financial markets; robots not only facilitate trade, but also increasingly trade. Menkveld will investigate whether the evolving new architecture is indeed (socially) better and, more importantly, identify new (systemic) risks and find out how these can be prevented.
|Paola Gori-Giorgi receives the Vici grant for her research into a new quantum mechanical approach to describe 'Van der Waals interactions' between molecules. By developing a new mathematical approach to describe 'Van der Waals interactions' in quantum mechanics, Gori-Giorgi hopes to make computer simulations in chemistry and materials science more reliable, affordable and energy-efficient.
|Halleh Ghorashi receives a Vici grant for her research into the contribution social science makes to realizing the democratic ideal of equality and inclusion of refugees. What are the possibilities and impediments of engaged science within different national and institutional (university) contexts?
|Serge Dumoulin will receive a Vici grant to conduct research into the dynamics of the human brain over the next five years. We live in a dynamic world. Our brains must be dynamic to deal with changing environments and tasks, but also stable so that brain functions are maintained throughout our lives. The research concerns a core function of the brain and attempts to build a theoretical framework for human brain dynamics.
|The biggest mountains on Earth, the Andes and Himalaya, formed over tens of millions of years. The forces responsible for building these mountains remain unclear. Wouter Schellart investigates the role of subducting tectonic plates and deep mantle flow in constructing and shaping these spectacular mountain ranges.||SCIENCE
|Humans can effectively scan their visual environment. Visual scanning is largely determined by peripheral vision – that is, what we can see from the corner of the eye. Chris Olivers investigates the relationship between peripheral perception and visual scanning in both behaviour and brain.||FGB||2016|
|Agnes Akkerman investigates how assertive employees are sometimes punished with poorer career chances or bullying by employers and colleagues. This research will reveal how and why the expression of dissatisfaction by employees is suppressed and what consequences this has.||FSW||2015|
|Bas van der Klaauw studies how the mismatch between education and the labour market has consequences for the acquisition of human capital.||SBE
|Anton Vonk Noordegraaf studies patients with pulmonary arterial hypertension. In these patients the blood vessels of the lungs are constricted, which means that the right ventricle has to work harder. Prof. Vonk will investigate whether the right ventricle can be ‘saved’ using new medicines or via a mechanical device.||VUmc||2015|
|Worldwide an area the size of the EU is burnt each year. Using new methods Guido van der Werf will investigate how fires influence the climate. He will use data about variations in the number of fires since the Industrial Revolution and he will determine whether fires have contributed to anthropogenic climate change or actually attenuated this.||SCIENCE
|Adaptation and plasticity of the brain is vital for adequate learning and adjustments in emotional processes. Sabine Spijker will study a new mechanism that encapsulates brain cells so that they are no longer capable of responding to stimuli in the environment. This results in emotional and memory problems.||SCIENCE
|Cells often have to deal with suddenly changing conditions. Furthermore, the number of components in a cell, such as proteins or RNA molecules, can randomly differ slightly per cell. Bas Teusink investigates the regulatory systems of metabolism in yeast that lead to robust adaptations in such an uncertain world.||SCIENCE
|Jeroen Aerts Global risks of flooding have strongly increased, mainly because people have moved to low-lying areas and vulnerable cities. Researchers will examine how this trend is influenced by human actions, and whether there are opportunities to reverse this trend.||SCIENCE
|Herbert Bos Through security leaks hackers penetrate into our most essential computer systems. The researchers will improve the security testing of software by using 'profile sketches' of security leaks and new techniques for finding such profile sketches in existing software (for which the source code is of course not available).||SCIENCE
|Marjolein van Egmond Our intestines accommodate many bacteria. A healthy immune system ensures that we do not become ill from these bacteria, whereas abnormal immune reactions can instead lead to chronic intestinal inflammation. This research will determine how the antibody IgA contributes to this balance.||VUmc||2013|
|Huib Mansvelder Thinking requires concentration. By switching brain cells on and off with laser light in an animal that is trying to concentrate, researchers will investigate how networks of neurons in the prefrontal cortex bring about attention and control.||SCIENCE
|Danielle Posthuma Many psychiatric diseases are caused by small errors in networks of genes. The researchers will devise new methods to detect these errors. It will also be investigated how all of these network errors can jointly lead to diseases such as schizophrenia, depression and autism.||SCIENCE
|Martine Smit Viruses produce receptor proteins that have been detected in brain tumours. How these viral proteins reprogram the cell and contribute to tumour growth will be unravelled. This knowledge is vital for the development of new strategies for the treatment of brain tumours.||SCIENCE
|Wim van Westrenen Even though the moon is completely dry now, moonstone research has revealed that the moon did contain water four billion years ago. This project will investigate how much moon water there was, when this ended up in the moon and when it disappeared. This will give a new view on the earliest water cycle of our own planet, where all of the indications have disappeared as a result of erosion and plate tectonics.||SCIENCE
|Jacintha Ellers investigates the driving forces and underlying mechanisms of trait loss and its evolutionary consequences in the context of ecological interactions.||SCIENCE
|Thomas Spijkerboer's research is about the relation between migration law and the rising number of border deaths.||LAW||2012|
|John Kennis investigates light-sensitive proteins with sophisticated laser techniques in order to steer life processes by means of light.||SCIENCE
|Lydia Krabbendam investigates to what extent cultural differences in social interactions can be observed at the level of the underlying mechanisms.||FGB||2011|
|Jan Bouwe van den Berg combines abstract topological methods with computer assisted analysis to study the nonlinear dynamics of pattern formation.||SCIENCE
|Roberta Croce investigates the fundamental processes of the light reactions of photosynthesis in plants and green algae.||SCIENCE
|Erwin Peterman will develop new microscopes to count and track individual motor proteins that drive living cells.||SCIENCE
|Sarah van Walsum's research project concerns migration and asylum law through the lens of (cross-border) family relations and family norms.||LAW||2010|
|Brenda Penninx examines whether depression accelerates the process of biological aging, and how this process can be stopped.||VUmc||2010|
|Theo Smit investigates the process of self-organisation which gives rise to optimal structures in connective tissues like cartilage and bone.||VUmc||2010|
|Andre Lucas is developing new models to measure change processes, such as assessing economic risks (for example a financial crisis).||SBE
|Johannes de Boer uses optical echo for its research showing fabric in hollow bodies (lung, bowel, bladder) using small endoscopes.||SCIENCE
|Gijs Wuite examines the physics of DNA protein interactions and biomechanical characteristics of viral capsids and cells.||SCIENCE
|Bregje Onwuteaka-Philipsen investigates the perspectives of patients in the final phase of their lives, particularly in relation to the question of the personal dignity of their treatment.||VUmc||2008|
|Jeroen Smeets examines how we combine different types of information when making deliberate movements.||FGB||2008|
|Eus van Someren expertise covers sleep, circadian rhythms, cognition, aging, thermoregulation, imaging and acquisition, and analysis of physiological and behavioral time-series.||VUmc||2007|
|Kjeld Eikema investigates attosecond electron dynamics in biomolecules and fundamental physics in atoms, with the help of intense, ultrafast frequency comb lasers.||SCIENCE||2007|
|Luuk Visscher is working on the development of computer simulations that zoom in on the place of action in a complex molecular system.||SCIENCE
|Reina Mebius examines developments in the immune system, with the emphasis on the formation of lymph nodes.||VUmc||2004|
|Gerard Steen conducts research on the use of metaphors in language, images, thought and communication in such genres as conversions, academic texts and literary fiction.
|Romano Orru investigates sustainable synthesis methods for making new molecules with applications in catalysis, medicines or high-quality materials.||SCIENCE
|Ronald Meester conducts research on spatial stochastic processes. His interest lies in critical behaviour, scaling limits and stationary distributions.||SCIENCE
|Maurice Janssen examines how the interaction between electrons and atoms in a photochemical reaction can be manipulated.
|Matthias Bickelhaupt develops chemical theories and methods for rationally designing molecules, nano-structures and materials as well as chemical processes toward these compounds, based on quantum mechanics and computer simulations.||SCIENCE
|Ronald Koes examines how the enormous morphological diversity of plant and animal species has come about through evolution and what genetic changes lie at the basis of this.||SCIENCE