Decoding Neuropeptid e Secretion
Brain cells communicate with each other by rel easing small vesicles with signaling substances. Some vesicles ensure rapid communication between brain cells. Others, called dense-core v esicles (DCVs), work more slowly and release substances that affect i mportant processes such as sleep, metabolism, stress and brain develo pment.
Although DCVs are important for the functioning of the b rain, we do not yet know exactly how their release is regulated and h ow this process is disrupted in brain diseases.
We have shown t hat brain cells precisely regulate their slow release of signals via DCVs using different proteins. These proteins determine when the vesi cles release their contents and how efficiently this happens. This fo rm of communication appears to work differently from the rapid signal transmission between brain cells.
An important conclusion is t hat the same proteins do not have the same role in all brain cells. T he type of brain cell therefore partly determines how these vesicles are controlled.
More information on the thesis
DESCRIPTION: Decoding Neuropeptide Secretion Brain cells communicate w ith each other by releasing small vesicles with signaling substances. Some vesicles ensure rapid communication between brain cells. Others , called dense-core vesicles (DCVs), work more slowly and release sub stances that affect important processes such as sleep, metabolism, st ress and brain development.Although DCVs are important for the functi oning of the brain, we do not yet know exactly how their release is r egulated and how this process is disrupted in brain diseases.We have shown that brain cells precisely regulate their slow release of signa ls via DCVs using different proteins. These proteins determine when t he vesicles release their contents and how efficiently this happens. This form of communication appears to work differently from the rapid signal transmission between brain cells.An important conclusion is t hat the same proteins do not have the same role in all brain cells. T he type of brain cell therefore partly determines how these vesicles are controlled.More information on the thesis END:VEVENT END:VCALENDAR