Long-Term Prognostic Pe rspectives of Cardiovascular Disease: Myocardium to Mind
With the improved treatment of acute cardiovascular events and an aging po pulation, the global landscape of cardiovascular care is increasingly shifting toward managing chronic cardiovascular disease. This transi tion is ongoing, as more patients live longer with the long-term cons equences of cardiovascular disease. In addition, cardiovascular disea se may contribute to the development of cognitive impairment, another major public health concern. These chronic complications profoundly impact quality of life and independence in daily life, while also pla cing a growing burden on healthcare systems, healthcare costs and soc iety. This thesis addresses two challenges in the current age of card iovascular care: (1) acute myocardial infarction (AMI) and its long-t erm complications, and (2) mechanisms through which cardiovascular di sease may lead to abnormal brain aging and cognitive impairment. Usin g insights from cardiovascular magnetic resonance (CMR), this work ai ms to explore the underlying pathophysiological processes in depth. T he first part of this thesis focuses on identifying high-risk subgrou ps among patients with acute myocardial infarction to improve seconda ry prevention strategies. The second part examines the role of cardio vascular disease in the pathophysiology of cognitive impairment, with the aim of better understanding the complex interplay of cardiac dys function, arterial stiffness, and vascular risk factors in their cont ribution to abnormal brain aging.
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DESCRIPTION: With the improved treatment of acute cardiovascular event s and an aging population, the global landscape of cardiovascular car e is increasingly shifting toward managing chronic cardiovascular dis ease. This transition is ongoing, as more patients live longer with t he long-term consequences of cardiovascular disease. In addition, car diovascular disease may contribute to the development of cognitive im pairment, another major public health concern. These chronic complica tions profoundly impact quality of life and independence in daily lif e, while also placing a growing burden on healthcare systems, healthc are costs and society. This thesis addresses two challenges in the cu rrent age of cardiovascular care: (1) acute myocardial infarction (AM I) and its long-term complications, and (2) mechanisms through which cardiovascular disease may lead to abnormal brain aging and cognitive impairment. Using insights from cardiovascular magnetic resonance (C MR), this work aims to explore the underlying pathophysiological proc esses in depth. The first part of this thesis focuses on identifying high-risk subgroups among patients with acute myocardial infarction t o improve secondary prevention strategies. The second part examines t he role of cardiovascular disease in the pathophysiology of cognitive impairment, with the aim of better understanding the complex interpl ay of cardiac dysfunction, arterial stiffness, and vascular risk fact ors in their contribution to abnormal brain aging. More information o n the thesis Long-Term Prognostic Perspectives of Cardiovascu lar Disease: Myocardium to Mind END:VEVENT END:VCALENDAR