Tailoring Prostate C ancer Surgery
This thesis studied and confirmed that image -guided surgery in prostate cancer is an innovative way to operate wi th greater precision. First, a systematic review was conducted of wha t was known worldwide at that time. This was studied more in depth th rough a Delphi consensus proces with international panel members. The wishes and requirements of daily practicioners of targeted surgery w ere analyzed, and gave us insights in how to proceed in future resear ch. To visualize anatomical structures, tracers can be used during su rgery to identify, for example, the sentinel lymph node or the lympha tic pathways in their entirety from the prostate (and other organs). To remove the tumor-containing tissue while sparing healthy tissue, a tracer that specifically binds to the prostate-specific membrane ant igen (PSMA) and is therefore selective for prostate cancer can be use d. Both fluorescence and radio-guided surgery are options here. The f ocus of this thesis is on the advantages and disadvantages of fluores cence and radio-guided applications. The ultimate goal is to develop a prostate-specific tracer that is both fluorescent and radioactive ( hybrid). The follow-up to this in the form of a “first-in-human” trial with the hybrid PSMA tracer is expected this year.
More i nformation on the thesis
DESCRIPTION: Tailoring Prostate Cancer Surgery This thesis studied and confirmed that image-guided surgery in prostate cancer is an innovat ive way to operate with greater precision. First, a systematic review was conducted of what was known worldwide at that time. This was stu died more in depth through a Delphi consensus proces with internation al panel members. The wishes and requirements of daily practicioners of targeted surgery were analyzed, and gave us insights in how to pro ceed in future research. To visualize anatomical structures, tracers can be used during surgery to identify, for example, the sentinel lym ph node or the lymphatic pathways in their entirety from the prostate (and other organs). To remove the tumor-containing tissue while spar ing healthy tissue, a tracer that specifically binds to the prostate- specific membrane antigen (PSMA) and is therefore selective for prost ate cancer can be used. Both fluorescence and radio-guided surgery ar e options here. The focus of this thesis is on the advantages and dis advantages of fluorescence and radio-guided applications. The ultimat e goal is to develop a prostate-specific tracer that is both fluoresc ent and radioactive (hybrid). The follow-up to this in the form of a “first-in-human” trial with the hybrid PSMA tracer is expected th is year.More information on the thesis END:VEVENT END:VCALENDAR