Beyond the droplet
This thesis explores analytical challenges and solutions in small- volume clinical chemistry, driven by the growing use of minimally inv asive sampling methods like capillary blood collection. It highlights the need for careful method optimization to ensure reliable results, especially considering factors such as hematocrit-related bias in dr ied blood spot (DBS) analysis. The research demonstrates that, for ce rtain analytes, DBS and small-volume samples can provide accurate res ults. The work also evaluates biomarkers and methods for screening fo r familial hypercholesterolemia (FH) in children, including the use o f free cholesterol as a potential marker and Microtainer serum tubes as a less invasive sample type. Overall, the findings offer practical strategies to improve the reliability and applicability of small-vol ume clinical chemistry in diagnostics and screening.
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DESCRIPTION: This thesis explores analytical challenges and solutions in small-volume clinical chemistry, driven by the growing use of mini mally invasive sampling methods like capillary blood collection. It h ighlights the need for careful method optimization to ensure reliable results, especially considering factors such as hematocrit-related b ias in dried blood spot (DBS) analysis. The research demonstrates tha t, for certain analytes, DBS and small-volume samples can provide acc urate results. The work also evaluates biomarkers and methods for scr eening for familial hypercholesterolemia (FH) in children, including the use of free cholesterol as a potential marker and Microtainer ser um tubes as a less invasive sample type. Overall, the findings offer practical strategies to improve the reliability and applicability of small-volume clinical chemistry in diagnostics and screening. More in formation on the thesis Beyond the droplet END:VEVENT END:VCALENDAR