Ovarian responsivene ss to gonadotropins
A central theme emerging from this the sis is that ovarian ageing and ovarian responsiveness are the result of a complex interplay between follicle quantity, oocyte quality, end ocrine regulation, and genetic variation. While ovarian reserve tests inform expectations regarding stimulation outcomes, they do not sole ly determine reproductive potential. Similarly, although genetic vari ants in FSHR modulate ovarian sensitivity, they do not significantly influence live birth outcomes nor justify routine dose escalation. Th e studies presented in this thesis further demonstrate that diminishe d ovarian reserve does not equate to a lack of functional ovarian res ponsiveness. Overall, the findings support a cautious, individualized , and evidence-based approach to ovarian stimulation, in which age, o varian reserve, and biological variability are jointly considered, ra ther than relying on single biomarkers or empiric dose escalation.
More information on the thesis
DESCRIPTION: Ovarian responsiveness to gonadotropins A central theme e merging from this thesis is that ovarian ageing and ovarian responsiv eness are the result of a complex interplay between follicle quantity , oocyte quality, endocrine regulation, and genetic variation. While ovarian reserve tests inform expectations regarding stimulation outco mes, they do not solely determine reproductive potential. Similarly, although genetic variants in FSHR modulate ovarian sensitivity, they do not significantly influence live birth outcomes nor justify routin e dose escalation. The studies presented in this thesis further demon strate that diminished ovarian reserve does not equate to a lack of f unctional ovarian responsiveness. Overall, the findings support a cau tious, individualized, and evidence-based approach to ovarian stimula tion, in which age, ovarian reserve, and biological variability are j ointly considered, rather than relying on single biomarkers or empiri c dose escalation.More information on the thesis END:VEVENT END:VCALENDAR