Cure and Care: Delic ate Balance in Global Pediatric Acute Myeloid Leukemia
β The most important factor determining whether a child diagnosed with cancer will survive is not the biology of the disease, but the countr y in which the child is treated.β This reflects the profound global disparities in childhood cancer outcomes. While survival exceeds 80% in high-income countries, it often remains below 30% in low- and mid dle-income countries, where most children with cancer live. This thes is focuses on pediatric acute myeloid leukemia (AML), a malignant dis order of the bone marrow with particularly poor outcomes in resource limited settings. Unfortunately, there is no simple cure for AML. Tre ating AML requires a careful balance between anti-cancer treatment an d supportive care: delivering sufficiently intensive treatment to ach ieve cure, while preventing treatment-related morbidity and mortality . This balance is highly context-dependent and shapes global survival differences. The studies presented provide a global perspective on p ediatric AML, identify new treatment strategies, and aim to enhance s upportive care. By combining global perspectives with clinical and tr anslational research, this thesis aims to contribute to more equitabl e, context-appropriate, and ultimately curative strategies for childr en with AML worldwide.
More information on the thesis DESCRIPTION: Cure and Care: Delicate Balance in Global Pediatric Acute Myeloid Leukemia βThe most important factor determining whether a child diagnosed with cancer will survive is not the biology of the di sease, but the country in which the child is treated.β This reflect s the profound global disparities in childhood cancer outcomes. While survival exceeds 80% in high-income countries, it often remains belo w 30% in low- and middle-income countries, where most children with c ancer live. This thesis focuses on pediatric acute myeloid leukemia ( AML), a malignant disorder of the bone marrow with particularly poor outcomes in resource limited settings. Unfortunately, there is no sim ple cure for AML. Treating AML requires a careful balance between ant i-cancer treatment and supportive care: delivering sufficiently inten sive treatment to achieve cure, while preventing treatment-related mo rbidity and mortality. This balance is highly context-dependent and s hapes global survival differences. The studies presented provide a gl obal perspective on pediatric AML, identify new treatment strategies, and aim to enhance supportive care. By combining global perspectives with clinical and translational research, this thesis aims to contri bute to more equitable, context-appropriate, and ultimately curative strategies for children with AML worldwide.More information on the thesis END:VEVENT END:VCALENDAR