BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Vrije Universiteit Amsterdam//NONSGML v1.0//EN NAME:PhD defence C. He METHOD:PUBLISH BEGIN:VEVENT DTSTART:20261022T094500 DTEND:20261022T111500 DTSTAMP:20261022T094500 UID:phd-defence-c-he@8F96275E-9F55-4B3F-A143-836282E12573 CREATED:20261025T172024 LOCATION:Main building VU, 1105, Aula, De Boelelaan, 1081 HV, Amsterdam SUMMARY:PhD defence C. He X-ALT-DESC;FMTTYPE=text/html:

Skeletal Muscle Cell Adaptations under Contractile, Pharmacological and Inflammatory Stre ss

Muscle Cells Under Stress: Recovery Is Not a M atter of Flipping a Switch

Using cultured muscle cells, He investigated how various stimuli influence the growth, energy metabo lism, and stress responses of muscle cells. The results show that med ications and inflammation-like stress can directly alter muscle cells . Beneficial stimuli, such as metformin or contraction-like stimulati on that mimics movement, were able to partially reduce some of the ne gative effects but did not lead to full recovery.

A key conclus ion is that muscle health is not determined by a single signal or a s ingle biological pathway. Restoring muscle function appears to be mor e complex than simply “flipping a switch.”

Many older adult s and people with chronic diseases experience muscle loss, which can lead to reduced independence and a lower quality of life. These new i nsights can help researchers and healthcare professionals better acco unt for the effects of medications, inflammation, and exercise on mus cles. In the long term, this could contribute to better prevention, m ore targeted treatments, and exercise programs that support healthy a ging.

More information about the dissertation

< /body> DESCRIPTION: Skeletal Muscle Cell Adaptations under Contractile, Pharm acological and Inflammatory Stress

Muscle Cells Under Str ess: Recovery Is Not a Matter of Flipping a Switch

Muscl e cells react strongly to their environment. This is evident from res earch by physiologist Chuqi He into the influence of factors that oft en occur together in aging and chronic disease, such as medication us e, mild inflammation, and reduced physical activity.Using cultured mu scle cells, He investigated how various stimuli influence the growth, energy metabolism, and stress responses of muscle cells. The results show that medications and inflammation-like stress can directly alte r muscle cells. Beneficial stimuli, such as metformin or contraction- like stimulation that mimics movement, were able to partially reduce some of the negative effects but did not lead to full recovery.A key conclusion is that muscle health is not determined by a single signal or a single biological pathway. Restoring muscle function appears to be more complex than simply “flipping a switch.”Many older adult s and people with chronic diseases experience muscle loss, which can lead to reduced independence and a lower quality of life. These new i nsights can help researchers and healthcare professionals better acco unt for the effects of medications, inflammation, and exercise on mus cles. In the long term, this could contribute to better prevention, m ore targeted treatments, and exercise programs that support healthy a ging.More information about the dissertation END:VEVENT END:VCALENDAR