Tailoring Prostate Canc er Surgery
This thesis studied and confirmed that image-guided surgery in prostate cancer is an innovative way to operate with grea ter precision. First, a systematic review was conducted of what was k nown worldwide at that time. This was studied more in depth through a Delphi consensus proces with international panel members. The wishes and requirements of daily practicioners of targeted surgery were ana lyzed, and gave us insights in how to proceed in future research. To visualize anatomical structures, tracers can be used during surgery t o identify, for example, the sentinel lymph node or the lymphatic pat hways in their entirety from the prostate (and other organs). To remo ve the tumor-containing tissue while sparing healthy tissue, a tracer that specifically binds to the prostate-specific membrane antigen (P SMA) and is therefore selective for prostate cancer can be used. Both fluorescence and radio-guided surgery are options here. The focus of this thesis is on the advantages and disadvantages of fluorescence a nd radio-guided applications. The ultimate goal is to develop a prost ate-specific tracer that is both fluorescent and radioactive (hybrid) . The follow-up to this in the form of a “first-in-human” trial w ith the hybrid PSMA tracer is expected this year.
More informat ion on the thesis
DESCRIPTION: This thesis studied and confirmed that image-guided surge ry in prostate cancer is an innovative way to operate with greater pr ecision. First, a systematic review was conducted of what was known w orldwide at that time. This was studied more in depth through a Delph i consensus proces with international panel members. The wishes and r equirements of daily practicioners of targeted surgery were analyzed, and gave us insights in how to proceed in future research. To visual ize anatomical structures, tracers can be used during surgery to iden tify, for example, the sentinel lymph node or the lymphatic pathways in their entirety from the prostate (and other organs). To remove the tumor-containing tissue while sparing healthy tissue, a tracer that specifically binds to the prostate-specific membrane antigen (PSMA) a nd is therefore selective for prostate cancer can be used. Both fluor escence and radio-guided surgery are options here. The focus of this thesis is on the advantages and disadvantages of fluorescence and rad io-guided applications. The ultimate goal is to develop a prostate-sp ecific tracer that is both fluorescent and radioactive (hybrid). The follow-up to this in the form of a “first-in-human” trial with th e hybrid PSMA tracer is expected this year. More information on the < a href="https://hdl.handle.net/1871.1/b5dd2820-7133-426c-9c79-b4418e1 08f5a" data-new-window="true" target="_blank" rel="noopener noreferre r">thesis Tailoring Prostate Cancer Surgery END:VEVENT END:VCALENDAR