BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Vrije Universiteit Amsterdam//NONSGML v1.0//EN NAME:PhD defence D.S. Roos METHOD:PUBLISH BEGIN:VEVENT DTSTART:20260303T134500 DTEND:20260303T151500 DTSTAMP:20260303T134500 UID:phd-defence-d-s-roos@8F96275E-9F55-4B3F-A143-836282E12573 CREATED:20260824T234743 LOCATION:Auditorium, Main building, 1105, (1st floor), De Boelelaan, 1081 HV, Amsterdam SUMMARY:PhD defence D.S. Roos X-ALT-DESC;FMTTYPE=text/html:

The telltale sign in Parkinson’s disease

The nose doesn't lie: loss of smell reveals more about Parkinson's than previously thought

We've known for a long time that a decline in the sense of smell occurs very early in people with Parkinson's disease, often se veral years before the first movement symptoms appear. Neurologist sp ecializing in movement disorders, Dareia Roos, investigated the role of smell loss from the very early stages, before movement symptoms ap pear, to the later, more advanced stages of the disease. She investig ated whether smell loss is related to the severity of various other s ymptoms associated with the disease, and whether this might have a pr edictive effect on the course of the disease.

Roos demonstrate s that olfactory disorders play a crucial role in both the onset and progression of Parkinson's disease. A decline in the sense of smell c an help identify people at higher risk for developing Parkinson's dis ease, but it can also help us better understand the progression of th e disease. Having a reduced sense of smell in people with Parkinson's disease appears to increase the risk of malnutrition and the likelih ood of cognitive decline. Performing smell tests, in combination with other tests and measurements, can ultimately contribute to better re cognition and treatment of people with Parkinson's disease.

Lo ss of smell is often seen as a harmless symptom, but this study shows that in Parkinson's, it can reveal a great deal about the risk of de veloping the disease, its progression, and potential consequences suc h as malnutrition and cognitive decline. The results are relevant for people with Parkinson's, their loved ones, and healthcare providers. A simple smell test could, in the future, help identify people at in creased risk earlier and improve patient monitoring and treatment ove r time.

A concrete example: a patient with Parkinson's and incr easing loss of smell can be additionally screened for nutritional pro blems or emerging cognitive changes, allowing for timely treatment an d support. This aligns with the current trend toward personalized car e and prevention in a society with a growing elderly population. Inte grating smell tests into clinical practice is accessible, inexpensive , and can be achieved in the short term, but only in combination with existing clinical and biological markers.
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DESCRIPTION: The telltale sign in Parkinson’s disease The no se doesn't lie: loss of smell reveals more about Parkinson's than pre viously thought

We've known for a long time that a de cline in the sense of smell occurs very early in people with Parkinso n's disease, often several years before the first movement symptoms a ppear. Neurologist specializing in movement disorders, Dareia Roos, i nvestigated the role of smell loss from the very early stages, before movement symptoms appear, to the later, more advanced stages of the disease. She investigated whether smell loss is related to the severi ty of various other symptoms associated with the disease, and whether this might have a predictive effect on the course of the disease.

Roos demonstrates that olfactory disorders play a crucial role i n both the onset and progression of Parkinson's disease. A decline in the sense of smell can help identify people at higher risk for devel oping Parkinson's disease, but it can also help us better understand the progression of the disease. Having a reduced sense of smell in pe ople with Parkinson's disease appears to increase the risk of malnutr ition and the likelihood of cognitive decline. Performing smell tests , in combination with other tests and measurements, can ultimately co ntribute to better recognition and treatment of people with Parkinson 's disease.

Loss of smell is often seen as a harmless symptom, but this study shows that in Parkinson's, it can reveal a great deal about the risk of developing the disease, its progression, and poten tial consequences such as malnutrition and cognitive decline. The res ults are relevant for people with Parkinson's, their loved ones, and healthcare providers. A simple smell test could, in the future, help identify people at increased risk earlier and improve patient monitor ing and treatment over time.A concrete example: a patient with Parkin son's and increasing loss of smell can be additionally screened for n utritional problems or emerging cognitive changes, allowing for timel y treatment and support. This aligns with the current trend toward pe rsonalized care and prevention in a society with a growing elderly po pulation. Integrating smell tests into clinical practice is accessibl e, inexpensive, and can be achieved in the short term, but only in co mbination with existing clinical and biological markers.
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