Ovarian responsiveness to gonadotropins
A central theme emerging from this thesis is that ovarian ageing and ovarian responsiveness are the result of a co mplex interplay between follicle quantity, oocyte quality, endocrine regulation, and genetic variation. While ovarian reserve tests inform expectations regarding stimulation outcomes, they do not solely dete rmine reproductive potential. Similarly, although genetic variants in FSHR modulate ovarian sensitivity, they do not significantly influen ce live birth outcomes nor justify routine dose escalation. The studi es presented in this thesis further demonstrate that diminished ovari an reserve does not equate to a lack of functional ovarian responsive ness. Overall, the findings support a cautious, individualized, and e vidence-based approach to ovarian stimulation, in which age, ovarian reserve, and biological variability are jointly considered, rather th an relying on single biomarkers or empiric dose escalation.
Mor e information on the thesis
DESCRIPTION: A central theme emerging from this thesis is that ovarian ageing and ovarian responsiveness are the result of a complex interp lay between follicle quantity, oocyte quality, endocrine regulation, and genetic variation. While ovarian reserve tests inform expectation s regarding stimulation outcomes, they do not solely determine reprod uctive potential. Similarly, although genetic variants in FSHR modula te ovarian sensitivity, they do not significantly influence live birt h outcomes nor justify routine dose escalation. The studies presented in this thesis further demonstrate that diminished ovarian reserve d oes not equate to a lack of functional ovarian responsiveness. Overal l, the findings support a cautious, individualized, and evidence-base d approach to ovarian stimulation, in which age, ovarian reserve, and biological variability are jointly considered, rather than relying o n single biomarkers or empiric dose escalation. More information on t he thesis Ovarian responsiveness to gonadotropins END:VEVENT END:VCALENDAR