BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Vrije Universiteit Amsterdam//NONSGML v1.0//EN NAME:PhD defence D.S. Roos METHOD:PUBLISH BEGIN:VEVENT DTSTART:20260303T134500 DTEND:20260303T151500 DTSTAMP:20260303T134500 UID:2026/phd-defence-d-s-roos@8F96275E-9F55-4B3F-A143-836282E12573 CREATED:20260414T104430 LOCATION:(1st floor) Auditorium, Main building De Boelelaan 1105 1081 HV Amsterdam SUMMARY:PhD defence D.S. Roos X-ALT-DESC;FMTTYPE=text/html:

The telltale sign in Pa rkinson’s disease

The nose doesn't lie: loss of smel l reveals more about Parkinson's than previously thought
We've known for a long time that a decline in the sense of smell occurs very early in people with Parkinson's disease, often several y ears before the first movement symptoms appear. Neurologist specializ ing in movement disorders, Dareia Roos, investigated the role of smel l loss from the very early stages, before movement symptoms appear, t o the later, more advanced stages of the disease. She investigated wh ether smell loss is related to the severity of various other symptoms associated with the disease, and whether this might have a predictiv e effect on the course of the disease.

Roos demonstrates that olfactory disorders play a crucial role in both the onset and progres sion of Parkinson's disease. A decline in the sense of smell can help identify people at higher risk for developing Parkinson's disease, b ut it can also help us better understand the progression of the disea se. Having a reduced sense of smell in people with Parkinson's diseas e appears to increase the risk of malnutrition and the likelihood of cognitive decline. Performing smell tests, in combination with other tests and measurements, can ultimately contribute to better recogniti on and treatment of people with Parkinson's disease.

Loss of s mell is often seen as a harmless symptom, but this study shows that i n Parkinson's, it can reveal a great deal about the risk of developin g the disease, its progression, and potential consequences such as ma lnutrition and cognitive decline. The results are relevant for people with Parkinson's, their loved ones, and healthcare providers. A simp le smell test could, in the future, help identify people at increased risk earlier and improve patient monitoring and treatment over time.

A concrete example: a patient with Parkinson's and increasing loss of smell can be additionally screened for nutritional problems o r emerging cognitive changes, allowing for timely treatment and suppo rt. This aligns with the current trend toward personalized care and p revention in a society with a growing elderly population. Integrating smell tests into clinical practice is accessible, inexpensive, and c an be achieved in the short term, but only in combination with existi ng clinical and biological markers.
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DESCRIPTION: The nose doesn't lie: loss of smell reveals more about Parkinson's than previously thought

We've known for a long time that a decline in the sense of smell occurs very ear ly in people with Parkinson's disease, often several years before the first movement symptoms appear. Neurologist specializing in movement disorders, Dareia Roos, investigated the role of smell loss from the very early stages, before movement symptoms appear, to the later, mo re advanced stages of the disease. She investigated whether smell los s is related to the severity of various other symptoms associated wit h the disease, and whether this might have a predictive effect on the course of the disease.

Roos demonstrates that olfactory disor ders play a crucial role in both the onset and progression of Parkins on's disease. A decline in the sense of smell can help identify peopl e at higher risk for developing Parkinson's disease, but it can also help us better understand the progression of the disease. Having a re duced sense of smell in people with Parkinson's disease appears to in crease the risk of malnutrition and the likelihood of cognitive decli ne. Performing smell tests, in combination with other tests and measu rements, can ultimately contribute to better recognition and treatmen t of people with Parkinson's disease.

Loss of smell is often s een as a harmless symptom, but this study shows that in Parkinson's, it can reveal a great deal about the risk of developing the disease, its progression, and potential consequences such as malnutrition and cognitive decline. The results are relevant for people with Parkinson 's, their loved ones, and healthcare providers. A simple smell test c ould, in the future, help identify people at increased risk earlier a nd improve patient monitoring and treatment over time. A concrete exa mple: a patient with Parkinson's and increasing loss of smell can be additionally screened for nutritional problems or emerging cognitive changes, allowing for timely treatment and support. This aligns with the current trend toward personalized care and prevention in a societ y with a growing elderly population. Integrating smell tests into cli nical practice is accessible, inexpensive, and can be achieved in the short term, but only in combination with existing clinical and biolo gical markers.
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