Beyond the droplet
This thesis explores analytical challenges and solutions in small-volume clinical chemistry, driven by the growing use of minima lly invasive sampling methods like capillary blood collection. It hig hlights the need for careful method optimization to ensure reliable r esults, especially considering factors such as hematocrit-related bia s in dried blood spot (DBS) analysis. The research demonstrates that, for certain analytes, DBS and small-volume samples can provide accur ate results. The work also evaluates biomarkers and methods for scree ning for familial hypercholesterolemia (FH) in children, including th e use of free cholesterol as a potential marker and Microtainer serum tubes as a less invasive sample type. Overall, the findings offer pr actical strategies to improve the reliability and applicability of sm all-volume clinical chemistry in diagnostics and screening.
Mor e information on the thesis
DESCRIPTION: Beyond the droplet This thesis explores analytical challe nges and solutions in small-volume clinical chemistry, driven by the growing use of minimally invasive sampling methods like capillary blo od collection. It highlights the need for careful method optimization to ensure reliable results, especially considering factors such as h ematocrit-related bias in dried blood spot (DBS) analysis. The resear ch demonstrates that, for certain analytes, DBS and small-volume samp les can provide accurate results. The work also evaluates biomarkers and methods for screening for familial hypercholesterolemia (FH) in c hildren, including the use of free cholesterol as a potential marker and Microtainer serum tubes as a less invasive sample type. Overall, the findings offer practical strategies to improve the reliability an d applicability of small-volume clinical chemistry in diagnostics and screening.More information on the thesis END:VEVENT END:VCALENDAR