Synthetic & Bio-organic Chemistry
The Synthetic & Bio-organic Chemistry research group of Prof. Dr. Ir. Romano Orru focuses on the development of highly efficient, asymmetric synthetic methodologies and their application to the synthesis of diverse, biologically relevant compounds, with an emphasis on atom and resource efficiency.
Three main areas of interest can be distinguished:
- Rational design and development of flexible novel cascade and multicomponent reactions (MCRs).
- Use of biocatalysts for the production of enantiopure building blocks for asymmetric synthesis.
- Development of asymmetric versions of MCRs and related processes using biocatalysis and/or homogeneous catalysis.
The group's efforts in this area have resulted in the development of several novel MCRs and other cascade reactions furnishing valuable heterocycles. Another goal is the integration of the group’s successes in MCR chemistry and biocatalysis in approaches towards the total synthesis of complex natural products.
Organic and Peptide Chemistry
The Organic and Peptide Chemistry research group headed by Prof. Dr. Tom Grossmann focuses on the design of peptide-derived molecules (so called peptidomimetics) as modulators of therapeutically relevant biological targets. The research focuses on three main areas:
- Stabilization of peptide secondary and tertiary structures
- Chemical post-translational modification of native proteins
- Structural Chemical Biology
The group has an expertise in the synthesis of non-natural amino acids, solid phase synthesis of modified peptides and heterologous protein expression. In addition, the biophysical characterization of ligands with proteins and oligonucleotides is performed using X-ray crystallography, isothermal titration calorimetry and fluorescence polarization assays (among others).
Group website: www.grossmannlab.com